I see that what weakens the union politically is the small number of Eurosceptic countries who have not become any more cooperative after these 15 years.
The cost of some countries opting out would need to be factored into the decision to go ahead, but since the EU already doesn't prevent member states from entering bilateral or multilateral arrangements, all I'm saying is that those should be made part of the EU structure.
Also, new applicants for membership don't get to opt out of anything. "It's the statue, man, The Statue."
Your problem is that Ireland is prevented by the UK from taking advantage of a certain enhanced cooperation (though you are in the Euro) "It's the statue, man, The Statue."