Even cultivated farmlands occupy only a small fraction of the empty areas on that map. Auferre, trucidare, rapere, falsis nominibus imperium; atque, ubi solitudinem faciunt, pacem appellant.
Yet back then there were still a few places where that might happen: Now, despite your map, there are vanishly few places on land where an explosion of that magnitude could happen and not have a considerable impact on a human population. keep to the Fen Causeway