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How does this information inform therapy of viral pneumonia, proximate cause of H1N1 death? Or justify a public health policy of indiscriminate vaccination with experimental media?

Diversity is the key to economic and political evolution.
by Cat on Sun Jul 12th, 2009 at 12:36:52 AM EST
[ Parent ]
How is it surprising that obese people would die more frequently from complications of flu? They start out with impaired lung function.

The peak-to-trough part of the business cycle is an outlier. Carnot would have died laughing.
by Migeru (migeru at eurotrib dot com) on Sun Jul 12th, 2009 at 05:08:38 AM EST
[ Parent ]
It's not surprising to me. What is "surprising" to me is the rhetorical significance of obesity assigned to H1N1 morbidity as compared to the gamut of "risk factors" also identified with infection.

Diversity is the key to economic and political evolution.
by Cat on Sun Jul 12th, 2009 at 10:42:53 AM EST
[ Parent ]
Let's see. When a vaccination campaign is carried out, "at risk" populations are vaccinated in preference to others, especially if there is not enough vaccine for everyone.

Normally the seasonal flu kills the elderly, those with preexisting respiratory conditions, etc. And so, those are the people who get vaccinated in preference.

In this case, if it is true that serious flu cases seem to belong to the 20-45 age bracket you don't have to vaccinate the elderly as you do in seasonal flu: you'd have to vaccinate the 20-45 age group.

Similarly, if it turns out that the mortality rate (given infection) is higher in obese people, you would consider vaccinating the obese in preference to other groups.

And so on.

So, yes, you would have to consider a gamut of risk factors both influencing susceptibility to infection and the severity of the disease.

The peak-to-trough part of the business cycle is an outlier. Carnot would have died laughing.

by Migeru (migeru at eurotrib dot com) on Sun Jul 12th, 2009 at 11:33:08 AM EST
[ Parent ]
m'K. Add to age, BMI exposure...

The bug is reported [country distribution page links to WHO map] to have killed 429 people worldwide since its discovery in the U.S. and Mexico in April. The infection, which has now spread as far as New Zealand and Norway, causes little more than a fever and cough in most cases. The majority of those who died were pregnant, had asthma, diabetes or  other chronic diseases, according to the WHO.

... and you get in effect (almighty cost-basis) a formula for indiscriminate vaccination in countries where >50% of the total population exhibit one or more of these "risk factors" in addition to age, BMI. The US ($1.85B) and UK, f'r instance where (purportedly it is NOT true "serious flu cases seem to belong to the 20-45 age bracket") chronic flatulence may constitute unacceptable infection risk at some indeterminate point in time.

5-day Vaccine Trial | Times | 12 July 2009

Regulators at the European Medicines Agency (EMEA) said the fast-tracked procedure has involved clinical trials of a "mock-up" vaccine similar [!!] to the one that will be used for the biggest mass vaccination programme in generations. It will be introduced into the general population while regulators continue to carry out simultaneous clinical trials. ...

The UK government has ordered enough vaccine to cover the entire population. GPs are being told to prepare for a nationwide vaccination campaign....

He said although swine flu was not causing serious illness in patients, health officials were eager to start a mass vaccination campaign, starting first on priority groups....

The Department of Health said it had still not finalised which groups would be vaccinated first, but children, frontline health workers, people with underlying illnesses and the elderly are likely to take priority.

Lemme tell you something: We are not discussing reasonable public health policy. We are not evaluating evidence of 'pandemic' morbidity or even therapeutic relief. We're watching a movie in which my child is a captive, unnamed extra.

Diversity is the key to economic and political evolution.

by Cat on Mon Jul 13th, 2009 at 09:51:16 AM EST
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