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Swine flu 'five times more virulent' | The Independent | 13.7.09
The first full analysis of the H1N1 virus, published in Nature, shows it causes more lung damage in animals than seasonal flu. For two strains of virus tested, five times less was needed to cause the same damage as seasonal flu. Damage to the lungs increases the risk of pneumonia which is the commonest cause of complications, severe illness and death in flu epidemics.
Is this really what is usually meant by "five times more virulent"?
by gk (g k quattro due due sette "at" gmail.com) on Mon Jul 13th, 2009 at 05:13:01 PM EST
[ Parent ]
ferrets: Were these ferrets morbidly obese or not?

I want to purchase this article:
Katharine Sanderson,"Swine flu reaches into the lungs and gut", Nature News (2 July 2009)

Price: US$8

In order to purchase this article you must be a registered user.



Diversity is the key to economic and political evolution.
by Cat on Mon Jul 13th, 2009 at 05:29:11 PM EST
[ Parent ]
and monkeys and mice as insufficient human tissue is available for autopsy or culture since April. How odd: "Tests showed swine flu multiplies in greater numbers across the respiratory system [a hint of systemic circulatory dysfunction?], and causes more damage. And instead of staying in the head like seasonal flu, it penetrates deeper into the respiratory tissues [lungs?] - making it more likely to cause pneumonia." Isn't that something. I'd no idea that seasonal flu afflicted only one's "head".

more revelations...

'Treatment Phase,' Course for 30M Brits | BBC | 2 July 2009

"Cases are doubling every week and on this trend we could see over 100,000 cases per day by the end of August." ...


Diversity is the key to economic and political evolution.
by Cat on Mon Jul 13th, 2009 at 06:41:13 PM EST
[ Parent ]
Can we declare an official WHO Health Hysteria Alert™ yet?

The numbers are clear. Out of tens of thousands of infections in the UK, people are dying in their tens. Barely.

I suppose it's lucky we're descended from apes and not from obese ferrets, or we'd really be in trouble.

by ThatBritGuy (thatbritguy (at) googlemail.com) on Mon Jul 13th, 2009 at 07:37:00 PM EST
[ Parent ]
...we're descended from apes and not from obese ferrets...

Are you certain about this?

As the Dutch said while fighting the Spanish: "It is not necessary to have hope in order to persevere."
by ARGeezer (ARGeezer a in a circle eurotrib daught com) on Mon Jul 13th, 2009 at 08:28:41 PM EST
[ Parent ]
Jury's still out.
by ThatBritGuy (thatbritguy (at) googlemail.com) on Mon Jul 13th, 2009 at 08:32:58 PM EST
[ Parent ]
Perhaps both?

As the Dutch said while fighting the Spanish: "It is not necessary to have hope in order to persevere."
by ARGeezer (ARGeezer a in a circle eurotrib daught com) on Tue Jul 14th, 2009 at 10:58:31 AM EST
[ Parent ]
Can we declare an official WHO Health Hysteria AlertTM yet?

No.

First, female employees must be sequestered;

Male model must be hired International Presenter™,

equipped with revised WHO script to acknowledge supreme leaders strep and CAP;

one 3m2 blackline anatomical drawing titled PNEUMONIA that illustrates

THERE IS NO DOOR BETWEEN NASAL CAVITY, MOUTH, AND LUNGS

and

WHERE LIVE MICRO-ORGANISMS DISPLACE AIR,

immune response also destroys "respiratory tissues";

and one 3m2 blackline technical drawing titled INTUBATION that illustrates

modern medicine,

THE ONGOING FAILURE TO INVENT RELIABLE CLINICAL TREATMENT OF ACUTE PNEUMONIAS,

increases probability of death

and professional panic.

Diversity is the key to economic and political evolution.

by Cat on Tue Jul 14th, 2009 at 01:02:49 AM EST
[ Parent ]
neato...

Michael M. Patterson, PhD, "The Coming Influenza Pandemic: Lessons From the Past for the Future", JOMA. 2005

....In 1918, C.P. McConnell, DO,11 reported that the most effective treatment during the influenza pandemic was begun early in the onset of symptoms (within the first 24 hours) and consisted of carefully applied muscular relaxation and, most importantly, relaxation of the deep and extensive contractions of the deep spinal musculature and mobilization of the spine. These treatments would be repeated two or three times early in the course of the infection, along with traditional supportive measures such as hydration. During later influenza epidemics, such as the 1928-1929 and the 1936-1937 outbreaks, various lymphatic pump treatments and more attention to the cervical and upper thoracic regions were added to this recommended treatment protocol.12 These treatments, individualized to each patient's needs, were apparently the most commonly applied osteopathic medical procedures during the epidemics.

It seems possible that the mechanisms of action of these treatments were to diminish somatic inputs from contracted muscles that had further stimulated the already overactive sympathetic system. This hyperreactivity exacerbated the counterproductive and deadly immune response. During the later phases of infection, osteopathic manipulative treatment (OMT) likely enhanced lymphatic drainage and encouraged appropriate immune response.

While we have no controlled data on the effects of OMT on the pandemic influenza, several studies have shown the effects of OMT on somewhat related diseases. For example, Noll et al13 demonstrated that OMT given to elderly patients with pneumonia decreases medication use and hospital stay. More recently, Knott et al14 showed in a canine model that lymphatic treatment greatly increases lymph flow in the thoracic duct....

ht energyecon ;)

Diversity is the key to economic and political evolution.

by Cat on Tue Jul 14th, 2009 at 02:34:15 AM EST
[ Parent ]
yea, DrMarketTrustee would get a kick out of that

Diversity is the key to economic and political evolution.
by Cat on Tue Jul 14th, 2009 at 02:37:47 AM EST
[ Parent ]
why, deep lower back massage works for him too?

great news about lymph drainage, this is one really powerfully helpful therapy, invented in Austria.

good catch, MT!

~"When an inner situation is not made conscious, it appears outside as fate." Karl Jung~

by melo (melometa4(at)gmail.com) on Tue Jul 14th, 2009 at 05:17:02 AM EST
[ Parent ]
if he were stll alive, melo, if. in his day he was possessed by extraordinary knowledge of physiology, physical and emergency medicine as well as unorthodox applications thereof.

then again, i'm sure he'd have been in a permanent, CNN-induced apoplectic state since March.

Diversity is the key to economic and political evolution.

by Cat on Tue Jul 14th, 2009 at 08:05:58 AM EST
[ Parent ]
You're to interpret "virulent" here to mean to the virus's fast rate of reproduction, ergo volume and  destuctive capacity.

While waiting its dread mutation, look! CAP and Pneumonia severity index.

There are over a hundred microorganisms which can cause CAP. The most common types of microorganisms are different among different groups of people. Newborn infants, children, and adults are at risk for different spectrums of disease causing microorganisms. In addition, adults with chronic illnesses, who live in certain parts of the world, who reside in nursing homes, who have recently been treated with antibiotics, or who are alcoholics are at risk for unique infections. Even when aggressive measures are taken, a definite cause for pneumonia is only identified in half the cases....

Viruses cause 20% of CAP cases.



Diversity is the key to economic and political evolution.
by Cat on Tue Jul 14th, 2009 at 01:46:08 AM EST
[ Parent ]
btw, i share your concern and distrust of mass compulsory vaccination.

knowing rummy is a part-owner of tamilflu does wonders for the immune system, lol!

~"When an inner situation is not made conscious, it appears outside as fate." Karl Jung~

by melo (melometa4(at)gmail.com) on Tue Jul 14th, 2009 at 05:22:28 AM EST
[ Parent ]
but wait. The venal quotient is bigger than he...or researchers scouring backmatter for correct dosages.

Lawsuit puts flu-vaccine contract in doubt | Nature | 30 June 2009

A US office tasked with readying the country for influenza pandemics received an unpleasant surprise last week, when creditors filed a lawsuit intended to force one of its new grantees into bankruptcy.

The lawsuit was filed the day before the Biomedical Advanced Research and Development Authority (BARDA) in Washington DC announced it had awarded a US$35-million contract to Protein Sciences, a biotechnology company in Meriden, Connecticut.



Diversity is the key to economic and political evolution.
by Cat on Tue Jul 14th, 2009 at 08:33:19 AM EST
[ Parent ]
That's what I don't get. I would have assumed, intuitively, that virulence referred to the damage it does to the patient. The rate of reproduction, or, in this case, the amount of the virus needed to cause a certain amount of damage, are presumably correlated to this. What I was questioning was the claim (presumably made by the journalist) that the same number (five) applies in all these cases.
by gk (g k quattro due due sette "at" gmail.com) on Tue Jul 14th, 2009 at 04:07:52 PM EST
[ Parent ]

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