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Ancient Brew Masters Tapped Antibiotic Secrets  

ScienceDaily (Sep. 2, 2010) -- A chemical analysis of the bones of ancient Nubians shows that they were regularly consuming tetracycline, most likely in their beer. The finding is the strongest evidence yet that the art of making antibiotics, which officially dates to the discovery of penicillin in 1928, was common practice nearly 2,000 years ago.

The research, led by Emory anthropologist George Armelagos and medicinal chemist Mark Nelson of Paratek Pharmaceuticals, Inc., is published in the American Journal of Physical Anthropology.

"We tend to associate drugs that cure diseases with modern medicine," Armelagos says. "But it's becoming increasingly clear that this prehistoric population was using empirical evidence to develop therapeutic agents. I have no doubt that they knew what they were doing."

Armelagos is a bioarcheologist and an expert on prehistoric and ancient diets. In 1980, he discovered what appeared to be traces of tetracycline in human bones from Nubia dated between A.D. 350 and 550, populations that left no written record. The ancient Nubian kingdom was located in present-day Sudan, south of ancient Egypt.

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Nelson, a leading expert in tetracycline and other antibiotics, became interested in the project after hearing Armelagos speak at a conference. "I told him to send me some mummy bones, because I had the tools and the expertise to extract the tetracycline," Nelson says....The results stunned Nelson. "The bones of these ancient people were saturated with tetracycline, showing that they had been taking it for a long time," he says. "I'm convinced that they had the science of fermentation under control and were purposely producing the drug."



As the Dutch said while fighting the Spanish: "It is not necessary to have hope in order to persevere."
by ARGeezer (ARGeezer a in a circle eurotrib daught com) on Sat Sep 4th, 2010 at 09:58:58 PM EST
[ Parent ]
So were they also intentionally breeding antibiotic resistant bacteria?  Wouldn't that have been the inevitable result of consuming low levels of antibiotics over a long period of time?
The stomach cramps, photo hypersensitivity, and teeth discoloration in children must have been delightful.
by Andhakari on Sun Sep 5th, 2010 at 02:44:14 AM EST
[ Parent ]
Perhaps the creation of drug resistant bacteria requires the wholesale contamination of entire landscapes, such as happens when anti-biotics are fed to chickens, pigs and cows. There are entire watersheds from Texas to the Dakotas where MDR bacteria thrive in the creeks and streams as well as in the soil of the surrounding lands.

As the Dutch said while fighting the Spanish: "It is not necessary to have hope in order to persevere."
by ARGeezer (ARGeezer a in a circle eurotrib daught com) on Sun Sep 5th, 2010 at 10:39:20 AM EST
[ Parent ]
"I'm convinced that they had the science of fermentation under control and were purposely producing the drug."

Fermentation under control ... fine. Purposely producing the drug (?)... something they had NO idea existed, in fact, they had no IDEA what EXISTED meant ...? Dear Mr. Scientist: Stick to your lab, do your analysis work, and then STFU.

In the end, might makes right. Nothing has changed since the caveman.

by THE Twank (yatta blah blah @ blah.com) on Sun Sep 5th, 2010 at 07:32:54 AM EST
[ Parent ]
Once he moves away from the physical anthropology and what can be reasonably inferred from that he is speculating. These people may have been aware of the healing effects of their beer and considered it a grace from their gods.

As the Dutch said while fighting the Spanish: "It is not necessary to have hope in order to persevere."
by ARGeezer (ARGeezer a in a circle eurotrib daught com) on Sun Sep 5th, 2010 at 10:44:26 AM EST
[ Parent ]
It was the chemist, Mark Nelson, who works for pharma, who was convinced they were consciously brewing the beer for its medicinal value. He was the one who had the apparatus to analyze the bones. The anthropologist, George Armelagos, undoubtedly had control over what went into the paper, but not over what came out of his chemist co-author's mouth. Anthropologists spend years learning what can and cannot be reasonably inferred about human behavior and thought. Medical chemists do not.

As the Dutch said while fighting the Spanish: "It is not necessary to have hope in order to persevere."
by ARGeezer (ARGeezer a in a circle eurotrib daught com) on Sun Sep 5th, 2010 at 10:55:09 AM EST
[ Parent ]
Brewing at that time was an entirely uncontrolled process using whichever wild yeasts blew into the brewing vessel.

they drunk beer and wine because it was safer than water, which would have all sorts of disease and parasites in it. Also boiling, which is a feature of beer making, further disinfects it. Alcohol gets rid of bad stuff too. So all in all, beer and iwne were amazing god-granted liqids.

They thought it was miraculous that a liquid could change like that, to them it was literally a work of divine grace. It was the breath of god, which they would notice because yeast give off CO2 which is heavy and feel dense, so the brewing room would have a funny atmosphere, breathing too much of god's divine breath was fatal so that was a proof of sorts.

That's why getting drunk was such a feature of religious ceremonies, gods of beer and wine.

So,as Twank points out, the chances of them doing this deliberately are somewhere close ot zero.

keep to the Fen Causeway

by Helen (lareinagal at yahoo dot co dot uk) on Sun Sep 5th, 2010 at 07:53:53 AM EST
[ Parent ]
Yeah, what she said!

In the end, might makes right. Nothing has changed since the caveman.
by THE Twank (yatta blah blah @ blah.com) on Sun Sep 5th, 2010 at 03:32:21 PM EST
[ Parent ]

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