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Drug quickly reverses Alzheimer's symptoms in mice

ScienceDaily (Feb. 9, 2012) -- Neuroscientists at Case Western Reserve University School of Medicine have made a dramatic breakthrough in their efforts to find a cure for Alzheimer's disease. The researchers' findings, published in the journal Science, show that use of a drug in mice appears to quickly reverse the pathological, cognitive and memory deficits caused by the onset of Alzheimer's. The results point to the significant potential that the medication, bexarotene, has to help the roughly 5.4 million Americans suffering from the progressive brain disease.

Bexarotene has been approved for the treatment of cancer by the U.S. Food and Drug Administration for more than a decade. These experiments explored whether the medication might also be used to help patients with Alzheimer's disease, and the results were more than promising.

Alzheimer's disease arises in large part from the body's inability to clear naturally-occurring amyloid beta from the brain. In 2008 Case Western Reserve researcher Gary Landreth, PhD, professor of neurosciences, discovered that the main cholesterol carrier in the brain, Apolipoprotein E (ApoE), facilitated the clearance of the amyloid beta proteins. Landreth, a professor of neurosciences in the university's medical school, is the senior author of this study as well.



The fact is that what we're experiencing right now is a top-down disaster. -Paul Krugman
by dvx (dvx.clt ät gmail dotcom) on Sun Feb 12th, 2012 at 01:34:14 PM EST
[ Parent ]
ah the Guiness treatment

Any idiot can face a crisis - it's day to day living that wears you out.
by ceebs (ceebs (at) eurotrib (dot) com) on Sun Feb 12th, 2012 at 04:24:49 PM EST
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So, buy some stock in the company that has the license on Targretin (bexarotene)?  From what I can tell, that's no longer Ligand, but a Japanese company called Eisai Co. Ltd. (Pharmaceuticals) -- ESALY.

'tis strange I should be old and neither wise nor valiant. From "The Maid's Tragedy" by Beaumont & Fletcher
by Wife of Bath (kareninaustin at g mail dot com) on Sun Feb 12th, 2012 at 05:57:26 PM EST
[ Parent ]
dvx:
has to help the roughly 5.4 million Americans suffering from the progressive brain disease.

oops, there go fox's ratings!

"We can all be prosperous but we can't all be rich." Ian Welsh

by melo (melometa4(at)gmail.com) on Mon Feb 13th, 2012 at 07:33:57 AM EST
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