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I hate to say it because it's really hard to fix without fixing the society that the large companies are rooted in first.
You first have to fix society at large, before you can do some things.
In any case the whole resistance issue poses some very interesting moral questions:
Can we risk treating a person insufficiently (and thus risk her health) to delay the spread of resistance?
This would be though questions even in a sane environment: without financial interests and with intelligent people.
If you think of financials station as a decision-making process, and if you examine the claim that only financialisation can create 'progress', the objective reality is that financialisation makes a species stupid.
Wouldn't under-treatment promote resistance?
That is the orthodox view (to which I fully subscribe).
In the case of malaria there is a general consensus that under-treatment (in the 50s, Thai-Cambodian border) was the cause for resistance emergence (actually not under-treatment, but presumptive treatment - chloroquine (CQ) in small doses in salt). This was a policy recommended by the WHO (I traced the first suggestion to a paper written in 1953).
There are people trying to introduce treatment with doses below clearance. Their rationale is based on mouse models. Problem is: mouse and lab models have a tradition of not being transportable to human field reality. For instance (and this is interesting in economic terms):
Lab models predicted that CQ resistance would be maintained because CQ-resistant parasite multiply faster than CQ-sensitive parasites. We now know that this is not true (CQ-resistance falls if CQ if removed). NOTE THE UNDERLYING (wrong in this case) REASONING: something that grows faster is more fit that something that grows slower (growth, growth, growth baby). It never crossed peoples minds that faster growth might mean, for instance, killing the host before transmission is possible.
But it is interesting to see that the "growth is always good" meme goes well beyond economics....
Bacteria, virus and protozoans might require very different approaches and it is not clear that one can transfer reasoning from one to the other.
HGT is probably the cause for multi-resistant bacteria. In malaria it is probably recombination of resistant genotypes (save one exception, through mitochondrial mutation)
Denying antibiotics to humans on account of the danger of building resistance seems bogus when industry is allowed to turn entire landscapes anti-biotic resistant. It is just that it is easier to let medical professionals harangue their patients than to confront big pharma and eleminate a practice that is sold as adding 1-3% growth to meat animals. If I get some chickens I will have my choice of medicated or non-medicated feed. As the Dutch said while fighting the Spanish: "It is not necessary to have hope in order to persevere."
Not giving an opinion here... just food for thought, really.
Actually the same reasoning applies to poverty disease control and eradication: You cannot control/eliminate/eradicate if you do not have a environment conductive to that: Try eliminate whatever-disease when there is a war going on. Or when people simply have other issues at hand like getting food for the day. You first have to fix society at large, before you can do some things.
So the eradication of European malaria was possible due to a high level of organisation in Europe?
I am reminded of the US based organisations that tried to fix things in China in the 20ies and 30ies - agriculture, energy, stopping female feet binding - only to run into problems relating to there being a civil war going on. A vote for PES is a vote for EPP! A vote for EPP is a vote for PES! Support the coalition, vote EPP-PES in 2009!
Interestingly I submitted a grant proposal to study the genetic basis of insecticide resistance (trying to move from parasites to vectors).
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