Indeed!  (From the article):

Purpose: This review addresses different aspects of testicular torsion from
the clinical perspective as well as the basic cellular and molecular events
responsible for the post-torsion testicular changes and pathology, including
tissue ischemia-reperfusion injury.

Take-away: If you get your underwear in a knot, make certain your testicles are not in them.

"It is not necessary to have hope in order to persevere."