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News in Brief: Chemical tied to intergenerational obesity    Science News
Mice ingesting the compound tributyltin pass effects to grandchildren

Exposure in the womb to a chemical used in PVC and ship paint promotes obesity in mice. And the effect is long-lasting: The mice's grandchildren were also fat despite no exposure to the chemical.

The work shows that the effects of an obesogen -- a chemical that encourages fat accumulation -- can be passed on to future generations not exposed to the chemical, researchers report online January 15 in Environmental Health Perspectives.

The compound tributyltin is often added to PVC as a stabilizer and to marine paint as an antifouling agent. Raquel Chamorro-García of the University of California, Irvine and colleagues fed pregnant mice tributyltin in their drinking water at quantities similar to what people might ingest through house dust and other sources. The mice gave birth to pups that developed more and larger fat cells, as well as fattier livers, compared with unexposed pups.

These changes appear to be permanent. The children and grandchildren of these mice also had increased amounts of body and liver fat. The findings confirmed previous work showing that tributyltin affects the function of a gene that regulates body fat production and reprograms certain stem cells to become fat cells rather than bone cells.

"It is not necessary to have hope in order to persevere."
by ARGeezer (ARGeezer a in a circle eurotrib daught com) on Tue Jan 22nd, 2013 at 01:01:53 PM EST

'tis strange I should be old and neither wise nor valiant. From "The Maid's Tragedy" by Beaumont & Fletcher
by Wife of Bath (kareninaustin at g mail dot com) on Tue Jan 22nd, 2013 at 02:27:58 PM EST
[ Parent ]
I strongly suspect that this is just one of many such chemicals we have allowed into our food chain. BPA is another. It is estrogenic and is found in plastic containers for soft drinks and in the lining of canned goods, among other places. In aquatic systems contaminated with BPA there is a high incidence of male sexual deformity in frogs.

"It is not necessary to have hope in order to persevere."
by ARGeezer (ARGeezer a in a circle eurotrib daught com) on Tue Jan 22nd, 2013 at 03:43:22 PM EST
[ Parent ]
BPA has come up on the radar over here too.

Bisphenol A - Sweden

From March 2011 it is prohibited to manufacture babybottles containing bisphenol A and from July 2011 they can not be bought in stores. On 12 April 2012, the Swedish government announced that Sweden will ban the endocrine disruptor Bisphenol A (BPA) in cans containing food for children under the age of three.[245]

Sweden's finest (and perhaps only) collaborative, leftist e-newspaper Synapze.se
by A swedish kind of death on Tue Jan 22nd, 2013 at 05:52:32 PM EST
[ Parent ]
EU Directive from a year ago.
by afew (afew(a in a circle)eurotrib_dot_com) on Wed Jan 23rd, 2013 at 01:54:25 AM EST
[ Parent ]
and then there's this (Mail Alert):

the 'toxic' gene hiding in GM crops

"Life shrinks or expands in proportion to one's courage." - Ana´s Nin

by Crazy Horse on Tue Jan 22nd, 2013 at 04:27:24 PM EST
[ Parent ]
Significantly, the EFSA researchers concluded that the presence of segments of Gene VI 'might result in unintended phenotypic changes'.

Such changes include the creation of proteins that are toxic to humans. They could also trigger changes in the plants themselves, making them more vulnerable to pests.

Critics say the revelations make clear that the GM approvals process, which has been in place for 20 years, is fatally flawed.

They argue the only correct response is to recall all of the crops and food products involved. Director of the campaigning group, GM Freeze, Pete Riley, said the discovery of the gene, 'totally undermines claims that GM technology is safe, precise and predictable'.

He said: 'This is a clear warning the GM is not sufficiently understood to be considered safe. 'Authorisation for these crops must be suspended immediately, and they should be withdrawn from sale, until a full and extended review of their safety has been carried out.'

The Mail seems an excellent vehicle for the dissemination of this information. Good on them.

"It is not necessary to have hope in order to persevere."
by ARGeezer (ARGeezer a in a circle eurotrib daught com) on Tue Jan 22nd, 2013 at 09:29:32 PM EST
[ Parent ]


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