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Genetic mechanisms of critical illness in Covid-19 | Nature |

Covid: Genes hold clues to why some people get severely ill | BBC News |

'Angry' cells

Scientists looked at the DNA of patients in more than 200 intensive care units in UK hospitals.

They scanned each person's genes, which contain the instructions for every biological process - including how to fight a virus.

Their genomes were then compared with the DNA of healthy people to pinpoint any genetic differences, and a number were found - the first in a gene called TYK2.

"It is part of the system that makes your immune cells more angry, and more inflammatory," explained Prof Baillie.

But if the gene is faulty, this immune response can go into overdrive, putting patients at risk of damaging lung inflammation.

by Oui on Fri Dec 11th, 2020 at 05:58:08 PM EST

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