I've idly been evaluating the immune deficiency AKA immunocompromised AKA immunosuppressed AKA autoimmunity leitmotif in First World "What We Know" industry propaganda since CLINICIANS diagnosed MS in me body 24 years ago--without benefit of genomic sequencing, pathological certainty, or Big Data mining correlative inferences d/b/a "biostatistics", incidentally.

Within the first 5 years of consultation with experts and armed with a rudimentary, secondary school education in biology, chemistry, and logic, I arrived at a conclusion, or plausible threshold, to my own risk management of malpractice by differential diagnoses: Apart from radical and cosmetic surgery and routine  mechanical recovery (bone-setting and "high-risk" organ replacement), moderne medical canon is a massive collection of misplaced precision populating descriptive speculations (primary research d/b/a "peer-reviewed" publications of abstruse and unreproducible experiments with eugenically mass-produced mice populations or eugenically mass-produced human stem cells) that has not advanced prescriptive (applied research) praxis in quite a number of "knowledge domains"--be that hematology, endocrinology, neurology, cardiology, neurology, pulmonology, or more exotic, discrete organizational divisions of uhhh sociology d/b/a abnormal health professions like epidemiologists, the accountants of defective electronic public health records.  

Accordingly, pharmacology dispensed to date is not well understood. Experts licensed to prescribe "therapeutic" formulae, approved for consumption by proprietors of government buildings, rarely encounter much less acknowledge the clinical consequences of their "bioethics" (duly noted by dearly departed Dr. MarketTrustee, my Robert). Much of analog isolated compounds, or mRNA classified, chemistry, is palliative and transitory in their effects d/b/a "disease modulating" chemistry AKA synthetic catalytic conversions expected to replace adverse chemical interactions and "normalized" homeostasis, which is not well understood either. IOW, complex interactions expressed by an "essentialized" schema of What we know about elements associated with regulation of "immune system" DNA organisms that metabolize RNA products.

atm, I hesitate to post an entry here describing my own experience reporting a confounding Rx reaction to combined "disease modulating" Rx1 and Rx2, because I've been advised by Drug 2 manufacturer's agent pharmacists and "nurse educators" as well my prescribing physician that no such ADR and no differential dosage "end-points"  have been published, so; more important, the  zeitgeist here seems to me not amenable to interrogation of units of measurement employed by experts to evaluate any pharmaceutical cost and benefit other than prescribed ineffectual SARS-CoV-2 retroviral agents d/b/a "vaccine hesitancy" and atavistic right-wing ideologues.