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the exquisite cell ACE "receptor", backed by the full faith and credit of FDA, EMA guaranteed purchase and patented "vaccine" production

López-Otín and Judith S. Bond, "Proteases: Multifunctional Enzymes in Life and Disease" (2008)

Thus, proteases regulate the fate, localization, and activity of many proteins, modulate protein-protein interactions, create new bioactive molecules, contribute to the processing of cellular information, and generate, transduce, and amplify molecular signals. As a direct result of these multiple actions, proteases influence DNA replication and transcription, cell proliferation and differentiation, tissue morphogenesis and remodeling, heat shock and unfolded protein responses, angiogenesis, neurogenesis, ovulation, fertilization, wound repair, stem cell mobilization, hemostasis, blood coagulation, inflammation, immunity, autophagy, senescence, necrosis, and apoptosis.
In terms of specificity, diversity is also a common rule. Thus, some proteases exhibit an exquisite specificity toward a unique peptide bond of a single protein (e.g. angiotensin-converting enzyme); however, most proteases are relatively nonspecific for substrates, and some are overtly promiscuous and target multiple substrates in an indiscriminate manner (e.g. proteinase K). Proteases also follow different strategies to establish their appropriate location in the cellular geography and, in most cases, operate in the context of complex networks comprising distinct proteases, substrates, cofactors, inhibitors, adaptors, receptors, and binding proteins, which provide an additional level of interest but also complexity to the study of proteolytic enzymes.
archived 3CL protease inhibitor (A/V molecular bio primer), feat. "wide spectrum" ivermectin therapeutic effect, a WHO designated "ESSENTIAL" medicine and NOBEL prize award (2015); nsp14 specimen mutations with characteristics of scientific racism; select FDA licensed antiretroviral "cocktails", feat. 6 patented, brand-name protease inhibitors
by Cat on Fri Dec 10th, 2021 at 06:28:35 PM EST
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