Herd Immunity .. Filling the Gaps | 50 comments (50 topical, editorial, 0 hidden)

Re: wut "breakthrough vaccine cases"? (none / 1)

Breakthrough [vaccine] COVID infections ~~after vaccination~~ can lead to ["]long-haul["] symptoms [of disease], Israeli study shows

[Brown University School of Public Health dean Dr. Ashish] Jha said he is troubled by the fact that young, healthy people would get so-called breakthrough infections within a few months of vaccination. Scientists expected ["]protection["] to wane over time, and they expected the vaccines to be less effective among older people and those with pre-existing health conditions. But that's not who got sick in this study.
[...]
The good news is none of the 39 [Israeli] people who got infected passed the coronavirus on to anyone else, according to the study, published Wednesday in the New England Journal of Medicine.

SARS-CoV-2 B.1.617.2 (Delta) Variant COVID-19 Outbreak Associated with a Gymnastics Facility -- Oklahoma, April-May 2021, CDC contact tracing

He said current vaccines are great at preventing serious infection deep in the lungs, but not at blocking infection in the upper airways [cranial olfactory bulb "blood-brain barrier"]. What's needed, he said, is a nasal-spray vaccine that would stop the coronavirus from taking hold at all.
[...]
The study followed about 1,500 Israeli health care workers for four months after they received the Pfizer-BioNTech vaccine. Anyone who tested positive more than 11 days after the second dose was considered a breakthrough case.

misplaced imprecision

Most had the alpha variant of the virus, which is more contagious than the original version [?], but less infectious than the delta variant that now accounts for most cases in the United States.

humor me

by Cat on Thu Jul 29th, 2021 at 03:13:02 PM EST
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Re: wut "breakthrough vaccine cases"? (none / 1)

CDC crisis management communications (not peer-reviewed for clinicaltrials.gov), How to savor "natural" and "experimental" antibody dependent enhancement (ADE), or gain of function, in the lab or in the wild!

'You're vulnerable': Delta variant substantially more contagious than other variants, CDC presentation warns

The agency had been criticized for making the [mask wardrobe] recommendation without adequately supporting its reasons for the policy shift. But the presentation, first made public by The Washington Post, appears to do just that. CDC declined to comment late Thursday on the slideshow or its contents.

The struggle to rationalize "technical" nomenclature and "evidence-base" data continues!

Once infected, though, vaccinated people are just as contagious as those without that ~~protection~~ vaccination -- meaning they need to wear a mask and keep their distance to avoid passing on the virus.
[...]
If more people had been vaccinated earlier this year, cases would not be rising now and a return to masking wouldn't be necessary [?], said Dr. Eric Topol, director and founder of the Scripps Research Translational Institute in La Jolla, California.
"We wouldn't be in this pickle if we'd had 70% of the population vaccinated," he said. "When you have more than half your population not (fully) vaccinated, you're vulnerable."
[...]
In one Israeli study, vaccinated people over 60 were shown to be 97% protected against the alpha variant, but only 85% protected against delta. "Ninety-seven percent is phenomenal, but 81%? [!]" Topol said. "We've got a bigger challenge than ever before."

soooo when everyone is a "silent spreader", no one is contagious?

In a study posted online this week by Pfizer and its collaborator [BWAH!] BioNTech, but not yet peer-reviewed, the companies found their vaccine to be effective for at least six months. Effectiveness topped 90% for that period, according to the study, which was largely conducted before the delta variant became widespread [O RLY?].
[...]
In a Tuesday briefing, CDC Director Dr. Rochelle Walensky downplayed the possibility that a vaccinated person could pass on the virus, without giving the details about the viral load [OG titer] contained in the slideshow.

reference
lab Wan et al., "Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry"
wild Li et al., "Viral infection and transmission in a large well-traced outbreak caused by the Delta SARS-CoV-2 variant"

by Cat on Fri Jul 30th, 2021 at 01:06:41 PM EST
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Re: wut NPI? (none / 1)

China races to curb Delta-fuelled COVID outbreak, worst in months

Authorities reported 328 symptomatic infections in July - almost equal to the total number of local cases from February to June.
[...]
More than 260 infections nationwide have been linked to a cluster in Nanjing city in eastern Jiangsu province, where nine cabin cleaners at an international airport tested positive on July 20. Hundreds of thousands have already been locked down in the province, while Nanjing has tested all 9.2 million residents twice.
[...]
After one asymptomatic case was discovered in Zhengzhou - the epicentre of recent deadly floods in central Henan province - city officials on Saturday ordered mass testing of all 10 million residents. The head of the city health commission was also sacked.
[...]
"The COVID vaccine's protection against the Delta variant may have somewhat declined, but the current vaccine still has a good preventative and protective effect against the Delta variant," said Feng Zijian, virologist at the Chinese Center for Disease Control and Prevention.

by Cat on Sat Jul 31st, 2021 at 04:41:02 PM EST
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< wipes tears > (none / 0)

Slide No.1: What we have here is a failure to communicate ... virulence.
NY Post: spreads like chicken pox

by Cat on Fri Jul 30th, 2021 at 02:37:31 PM EST
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Re: wut "virulence"? (none / 0)

Slide No.6 vaccine efficacy (VE)

by Cat on Fri Jul 30th, 2021 at 02:51:27 PM EST
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Re: wut "breakthrough vaccine cases"? (none / 0)

Slide No. 12: "Communication challenges around VE and differential risk [of no-low-moderate-severe COVID-19 disease]"

Slide No. 14: Spreads like chicken pox (disease) or varicella (virus), possibly shingles (the disease caused by asymptomatic varicella-zoster virus SLEEPER CELLS!!1!).
Story developing ...

by Cat on Fri Jul 30th, 2021 at 03:12:07 PM EST
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Re: wut "virulence"? (none / 1)