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National MS Society featured that Harvard study of VA dependents in their monthly newsletter emailed 20 Jan 2022.
The National MS Society invested in this study as part of its ongoing research commitment to ending MS. [...] The Harvard team used blood samples collected to test for HIV among more than 10 million active-duty United States military personnel between 1993 and 2013. Looking for specific antibodies that signal past infection, they determined the EBV status at the time the first sample was taken, and then followed additional samples to determine the relation between EBV infection and MS onset during the period of active duty. The team identified 801 people who developed MS and 1,566 controls without MS whose samples were available. [...] Using a novel tool called VirScan, which screens for evidence of an immune response [antibodies] to approximately 200 viruses, they also found no links between other viruses and MS risk.
On the environmental side, major risk factors include geographical latitude (higher incidence in more temperate climates), which may reflect seasonal changes in sunlight exposure influencing vitamin D levels or pathogens prevalent in these regions, although a genetic contribution is possible as well. Tobacco exposure, obesity, and mononucleosis are also associated with enhanced risk for developing MS. Mononucleosis results from infection by Epstein-Barr virus in the post-pubertal population, and only a minority of people with a history of mononucleosis (and a tiny minority of all those infected with the nearly ubiquitous Epstein-Barr virus) eventually develop MS. Viruses other than Epstein-Barr have been suggested as potential causes of MS or MS-related disease activity, but none has been definitively proven. Some of these may act as molecular mimics...
The only research breaking ground in org chem is sm molecule wght (BBB) mRNA in vitro experiments to switch progenitor neurons (OLGs) on and off as well as T- and B-cells. There's also a small body of clinical trials testing metabolic anti-imflammatory MoAs.
* I didn't subscribe to MS Society or MS Foundation at all until 2021. I'd been advised by PC and neuro case workers that these organizations could provide transpo vouchers to med appointments. That turned out to be false.
Another is that latent viruses in the body, such as the Epstein-Barr [and varicella-zoster] virus that causes mononucleosis [that causes "shingles"], are reactivated. A recent study in the journal Cell pointed to Epstein-Barr in the blood as one of four possible risk factors, which also include pre-existing Type 2 diabetes and the levels of coronavirus RNA and certain antibodies in the blood. Those findings must be confirmed with more research. A third theory is that autoimmune responses develop after acute COVID-19. In a normal immune response, viral infections activate antibodies [T-cell, B-cell] that fight invading virus proteins. But sometimes in the aftermath, antibodies remain ["]revved up and mistakenly attack["] normal cells. That phenomenon is thought to play a role in autoimmune diseases such as lupus and multiple sclerosis
A third theory is that autoimmune responses develop after acute COVID-19.
In a normal immune response, viral infections activate antibodies [T-cell, B-cell] that fight invading virus proteins. But sometimes in the aftermath, antibodies remain ["]revved up and mistakenly attack["] normal cells. That phenomenon is thought to play a role in autoimmune diseases such as lupus and multiple sclerosis
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