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Nobel Prize Medicine - It's Personal

by Oui Tue Oct 2nd, 2018 at 01:13:54 PM EST

Thank you doctor Allison for your dedication and excellent work ... the basic science is now used in cancer treatment I need to lengthen the years I have left to live. I'm almost through the first six months of chemotherapy and will build further resistance with immunotherapy. I'm doing fine and still manage to do all my activities although in close harmony with my energy level and being aware of the needs of my physical well being.

Furthermore great appreciation for the Dutch healthcare insurance where no one is excluded and my treatment started in a matter of weeks after all tests were performed.

More below the fold ...


James P Allison and Tasuku Honjo win Nobel prize for medicine | The Guardian |

Two scientists who discovered how to harness the body's immune system to fight cancer have won the 2018 Nobel prize in physiology or medicine.

James Allison, of the US, and Tasuku Honjo, of Japan, will share the 9m Swedish kronor (£775,000) prize, announced by the Nobel assembly at the Karolinska Institute in Stockholm.

The scientists' groundbreaking work on the immune system has paved the way for a new class of cancer drugs that are already dramatically changing outcomes for patients. It is the first time the development of a cancer therapy has been recognised with a Nobel prize.

Allison said he was in a "state of shock" about having achieved "every scientist's dream".

...
The immune system normally seeks out and destroys mutated cells, but cancer finds sophisticated ways to hide from immune attacks. One way is by ramping up braking mechanisms designed to prevent immune cells from attacking normal tissue. In the 1990s, Allison discovered the first of these built-in brakes, known as checkpoints. Other teams were investigating the potential of enhancing the action of checkpoints to treat autoimmune diseases, but Allison showed that doing the reverse - switching off the brakes - could produce remarkable results in treating mice with cancer.

The Texas T Cell Mechanic

    "Once you've generated T cells that can
    recognize cancer, you've got them basically
    for the rest of your life."

James Allison, Ph.D., knows his T cells. For the past 30 years, he's studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology.

In the early 1980s, Allison was one of the first to identify the T cell receptor--the part of a T cell that binds to antigen and functions as the T cell's ignition switch. A few years later, in 1992, he showed that a molecule called CD28 functions as the T cell's gas pedal. Then, in 1995, when no one else was even thinking there would be such a thing, he identified the T cell's brakes, in the process opening up a whole new vista in cancer treatment.

Known as checkpoint blockade, the treatment approach uses antibodies to block the action of this braking molecule, called CTLA-4. By "taking the brakes off" the immune response, the treatment enables a more powerful anti-cancer response.

Some of the most dramatic clinical responses seen in recent years have occurred with checkpoint blockade antibodies, including ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1). Fittingly, in 2013, Science magazine named cancer immunotherapy the "breakthrough of the year," citing Allison's work in particular.

James Allison Has Unfinished Business with Cancer

Miracle drugs

The drug, the first of the checkpoint inhibitors, would become known as ipilimumab or Yervoy, and it is now sold by Bristol-Myers Squibb, a pharmaceutical company headquartered in Manhattan. Human studies began around 2000 on 14 patients stricken with metastatic melanoma, who were steeling themselves for their finals days in hospice. But after the trial began, three saw their tumors shrink. Allison, who moved to New York City's Memorial Sloan Kettering in 2004 to be closer to the trials, soon met one of the patients his drug had saved. Sharon Belvin was in her 20s, and had just finished college and gotten married, when metastatic melanomas appeared in her lungs, liver, and brain. She was terminal by the time her physician enrolled her in the first phase II clinical trial. The day Allison met her, she'd been in remission for a year.

Display:
I am envious no matter what you say about Rutte. I'd trade him in hot minute for the healthcare system there.

< sigh >

I finally entered secondary progressive MS last summer. Exactly 20 years from onset. And I'm a control.

Diversity is the key to economic and political evolution.

by Cat on Tue Oct 2nd, 2018 at 01:50:48 PM EST
It is axiomatic in European politics for conservatives to take for granted, and even take credit for, political innovations by progressives they opposed, and proceed to look for cutbacks, "efficiencies", and improved targeting of benefits even though there is no evidence of abuse or excess cost. It plays well with their constituencies who regard tax as theft, state benefits as an attack on freedom of choice, and state healthcare as an interference in the right to die without dignity...

Index of Frank's Diaries
by Frank Schnittger (mail Frankschnittger at hot male dotty communists) on Tue Oct 2nd, 2018 at 03:59:20 PM EST
[ Parent ]
It's not insurance that worries me. I'm not all that familar with the market in the Netherlands, but, sheesh, value for EUR is obvious.

I envy the research commitment.

Nothing gets done in the US unless it makes money. "Evidence-based" rubrics are a sham for the most mundane procedures. Wait. I mean, diagnostic testing. It's tough to get to the end of that buffet table ...

Diversity is the key to economic and political evolution.

by Cat on Tue Oct 2nd, 2018 at 06:00:56 PM EST
[ Parent ]
Ireland employs an unhealthy hybrid private insurance/state benefit model of healthcare, but in many western European democracies, private insurance is a luxury only the super rich require. Standard state benefits are more than adequate to meet virtually all real healthcare needs. Even in Ireland, if you are really ill, it's best to go to a public hospital, as they employ the best protocols and don't cherry pick only money making procedures. I distrust doctors whose clinical choices may be influenced by their profit margins...

Index of Frank's Diaries
by Frank Schnittger (mail Frankschnittger at hot male dotty communists) on Tue Oct 2nd, 2018 at 06:44:45 PM EST
[ Parent ]
me, too.


Diversity is the key to economic and political evolution.
by Cat on Tue Oct 2nd, 2018 at 07:42:24 PM EST
[ Parent ]
When I was 22 years old, just got my college degree, I made a decision to take a new look In Europe for employment.

I had two job offers with all emoluments for Blue Cross health care plan, in time a pension fund, nice starting salary, work in the MIC, got my high security clearance ...

Basically, I determined it was not worth the downside of high risks: angst, gun violence, war policy, health care once you lost your job or in case of becoming handicapped. At the age of sixteen I earned money mowing lawns in a more affluent suburb in St. Louis County. An elderly couple I got to know real well. The husband had been a ranger up North and had done quite well. He served the best meat I have ever eaten. Both were in the seventies and had painstaking health issues. I cost them a small fortune and would bring them in some financial peril. A lifelong success story, wealth and a beautiful home ... a chance this would just evaporate. I was asked to drive them to the Mayo clinic in Minneapolis by car (big Cadillac) and drive back home by myself. This was certainly another reminder that the American Dream is an illusion ... reserved for a small group where luck plays a role.

In just a few years I was witness when two Dutch immigrant families had to return to the Netherlands due to misfortune: a husband killed in a car accident, father of two young children, and a highly professional chemical engineer lost his residence permit when a teenage son was arrested for shoplifting with some friends.

In the Netherlands I had been uncertain whether I made the smart decision for a long time. For the past twenty years I have felt quite comfortable and have been quite happy. I have been in excellent health over all the years, really never been sick even for a single day ... until end of March this year. Now living longer than I would have if I had stayed in the US. Big smile! :)

Global Warming - distance between America and Europe is steadily increasing.

by Oui on Tue Oct 2nd, 2018 at 06:39:27 PM EST
[ Parent ]
Nothing in the US makes sense without taking racism into account.  The US doesn't have a modern health care system because whites don't want blacks to have access to modern health care.  

It would be nice to say the problem is southern whites, nice but inaccurate

She believed in nothing; only her skepticism kept her from being an atheist. -- Jean-Paul Sartre

by ATinNM on Wed Oct 3rd, 2018 at 03:55:46 PM EST
[ Parent ]
I look forward to see how Europeans will express race discrimination (read: nationalism, xenophobia) in a number of public policy disciplines where functionaries are unaccustomed to cost/benefit analysis by race or "country of origin". The temptation to ignore disparity in demographic detail will be mighty.

Diversity is the key to economic and political evolution.
by Cat on Wed Oct 3rd, 2018 at 04:45:46 PM EST
[ Parent ]
I suspect they will respond like people usually respond: badly.  Japanese, for example, are spending huge sums of money on robotics so they can fill the labor force without being forced to accept immigration.

She believed in nothing; only her skepticism kept her from being an atheist. -- Jean-Paul Sartre
by ATinNM on Wed Oct 3rd, 2018 at 07:19:02 PM EST
[ Parent ]
The alt-right movement has merged with the Conservatives in the US and UK. That's what Brexit and election of Trump was all about. I have written for a decade  on the leftist blogs about this fusion. After the [predicted] defeat of HRC in the presidential election of 2016 my analysis came under attack for heresy. Progressive Democrats? An endangered species ...

Just recently came across a person who has operated under the radar. Not once mentioned on this blog and really only once @BooMan in 2005. Jared Taylor [American Renaissance] is one of thousands of operatives paid for by the billionaires supporting chaos in our democratic institutions. Propaganda and a tranquil media do the rest.

Private meeting Jared Taylor with Dutch politician Thierry Baudet
Erkenbrand, alt-right in Netherlands

Three states with power have used the alt-right movement to secure votes in gaining a majority in elections: Israel - United Kingdom and the United States.  

Related reading:

Democratic Ideologues, Populism and Identity Politics
Global Xenophobia and Historical Amnesia

Global Warming - distance between America and Europe is steadily increasing.

by Oui on Wed Oct 3rd, 2018 at 07:39:02 PM EST
[ Parent ]
What YouTube Offers Right-Wingers -- National Review

AIN personalities tend to package their philosophy and policy alongside reactionary or attention-getting content, building brands that include rants, mini documentaries, and long-form interviews that can last hours. Their millions of followers tend to see them as trustworthy, authentic, and accountable -- three qualities Lewis identifies as the foundations of a successful channel. Such channels also typically evince a tone of edginess -- even danger. Iconoclasm is the norm. Lewis calls it a paradoxical mix of "hyper-traditional ideals with the rebellious positioning of past countercultural movements."

This serves as an important reminder of how increasingly common it is for young people to embrace anti-Left politics out of a desire to rebel. The success of the AIN is but one symptom of a larger evolution of the conservative disposition away from Burkean instincts of caution and respect in favor of juvenile defiance and distrustfulness.

by das monde on Thu Oct 4th, 2018 at 09:22:27 AM EST
[ Parent ]
There is no scenario in which these young men do not one day become an influential force in right-of-center politics, as either voters, consumers, or perhaps even media personalities or politicians themselves.
Where are the young women in this story?

archived
#WalkAway, June 2018

Diversity is the key to economic and political evolution.

by Cat on Thu Oct 4th, 2018 at 01:09:08 PM EST
[ Parent ]
Google gives something on "conservative young women":

conservativewomen.uk

An event in Dallas

7 resources ...

by das monde on Thu Oct 4th, 2018 at 01:38:29 PM EST
[ Parent ]
You're barking up the wrong tree, laddie!
For "conservative" rebels of a certain age ya gotta hit the SJW button.

Diversity is the key to economic and political evolution.
by Cat on Thu Oct 4th, 2018 at 03:08:47 PM EST
[ Parent ]
by das monde on Thu Oct 4th, 2018 at 03:40:36 PM EST
[ Parent ]
Alrighty then.

Sexual ambivalence is a start, rather an artifact of eurocentric THIRD WAVE political rebellion against patronizing ideology --chiefly, iconography, role play, as in The Handmaid's Tale.

Define the term "conservative" or "right-wing" or "far-right": Who? What? Where? How does ideology proscribe the political and moral authority of "women" (and minorities)?

Apply to theory and practice of SJW (FIFTH WAVE) "issue-oriented" rebellion. Identify effects of "women's liberation" from not-liberal institutions, if any that are attributable to this "movement" --besides safe spaces and whisper lists.

archived
Economists urged to use fertility to predict recessions
The Evolutionary Origins of Patriarchy

Diversity is the key to economic and political evolution.

by Cat on Thu Oct 4th, 2018 at 04:51:32 PM EST
[ Parent ]
Sexual ambivalence is played without definitions.

Turning to bad boys is a classic of "dialectic rebellion".

by das monde on Thu Oct 4th, 2018 at 05:09:59 PM EST
[ Parent ]
Sexual ambivalence is played without definitions.

Anarchy in theory? Find me that SJW manifesto, pls, or policy in practice --from anywhere.


Diversity is the key to economic and political evolution.

by Cat on Thu Oct 4th, 2018 at 05:22:17 PM EST
[ Parent ]
Manifestos are BS
by das monde on Thu Oct 4th, 2018 at 05:36:33 PM EST
[ Parent ]
That doesn't stop people from forming committees with beverages, writing them, then publishing them for people who weren't invited to the committee to read.

Literacy is satan, you know.

Diversity is the key to economic and political evolution.

by Cat on Thu Oct 4th, 2018 at 07:08:10 PM EST
[ Parent ]
by das monde on Tue Oct 2nd, 2018 at 02:04:55 PM EST
2018 physics Nobel Prize honors 3, including first woman in 55 years
When a reporter asked her how it felt to be only the third woman in history to be so honored, Strickland replied, "Really? Is that all? I thought there might have been more," adding, "I don't know what to say. I'm honored to be one of those women."

Marie Curie shared the prize in 1903 with Henri Becquerel and her husband Pierre Curie for their work on radioactivity. Maria Goeppert-Mayer shared the 1962 prize with E. Paul Wigner and Hans Jensen for her work on the shell structure of atomic nuclei.

by Bernard on Wed Oct 3rd, 2018 at 06:35:11 PM EST
[ Parent ]
Oui, would you speak about your experience with "informed consent" instrument(s) presented by health care providers of this treatment?

Diversity is the key to economic and political evolution.
by Cat on Wed Oct 3rd, 2018 at 04:49:56 PM EST
I'll have to read up about the term and definition ...

Informed consent for clinical treatment

I have not been limited in any way or confronted with the costs of this treatment. There hasn't been any delay from the moment an abnormality was found in a standard blood test. Within days I met the specialist oncology who initiated all necessary tests before a full diagnosis was determined and a choice of treatment was proposed.

I was offered the standard treatment for my case as the latest cancer research has found most effective. And I was offered an alternate route to participate in an experimental setting with another hospital. It took me no more than ten seconds to decline that offer.

Global Warming - distance between America and Europe is steadily increasing.

by Oui on Wed Oct 3rd, 2018 at 06:21:06 PM EST
[ Parent ]
term and definition:  There are many. Nomenclature varies according to time, country, and convenience. Did you know that "brain-death" is a controversial term in the medical profession to signify "real" death. Why? Families of patients resist ideation of death's finality ... resistance hinders timely organ harvest.

Filed in "bio-ethics": informed consent. I have a few books in my stacks that are somewhat dated. I got them, while researching subject matter pertaining to so-called best practices in "knowledge management."

Thank you for responding.

Diversity is the key to economic and political evolution.

by Cat on Wed Oct 3rd, 2018 at 07:00:55 PM EST
[ Parent ]


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