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Chloroquine Clinical Trials - Oxford U & Bill Gates

by Oui Thu May 21st, 2020 at 06:18:31 AM EST

University of Oxford
Information provided by (Responsible Party):
University of Oxford

Chloroquine/ Hydroxychloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting (COPCOV) | US Gov't NIH Clinical Trials |

More below the fold ...,

COVID-19 Therapeutics Accelerator Awards $20 Million in Initial Grants to Fund Clinical Trials | Gates Foundation |

Three Weeks, Two Drug Trials: An update on the Therapeutics Accelerator with Trevor Mundel | Bill & Melinda Gates Foundation |

Inaugural lecture from Martin Llewelyn: Disappearance of 'Professional' Pathogens

These trials had been started in March ... hmm

Trump Says FDA Approved Anti-Malaria Drug Chloroquine To Test As Coronavirus Treatment | Forbes – March 19, 2020 |

President Trump said in a press briefing that chloroquine and hydroxychloroquine, drugs used to treat malaria and severe arthritis, were approved by the Food and Drug Administration to test as a COVID-19 coronavirus treatment, as the number of cases nationwide continues to increase.

  • The drugs will be used in a clinical trial, according to FDA commissioner Dr. Stephen Hahn, who spoke during the press briefing.
  • Trump also said that other antiviral medications will be fast-tracked for FDA approval.
“What’s also important is not to provide false hope,” said Hahn, who spoke after Trump, adding, “We may have the right drug, but it might not be in the appropriate dosage form right now, and it might do more harm than good.”

What to watch for: Any updates on hydroxychloroquine, chloroquine or other treatments. Trump said he spoke to New York Governor Andrew Cuomo about chloroquine, and that the governor wanted to be “first in line” to access the drug for the state’s 4,100 coronavirus patients.

Fast forward …

Trump says he takes hydroxychloroquine to prevent coronavirus infection even though it’s an unproven treatment | CNBC |

Trump allies identifying pro-Trump doctors to publicly support his views

Trump allies are working on an initiative to have pro-Trump doctors publicly support the president and his views, multiple senior Trump campaign official confirmed to CBS News. The move comes amid the president's determination to boost the economy, which has been ravaged by the deadly coronavirus.

"The purpose of campaign coalitions is to amplify and promote President Trump's accomplishments and point of view. The president has been outspoken about the fact that he wants to get the country back open as soon and as safely as possible because there are also health risks associated with a prolonged lockdown," Trump campaign communications director Tim Murtaugh said. "There are a lot of doctors who agree with that and support what the President has done to combat the coronavirus."

French doctor …

The French Renegade Scientist Behind Chloroquine, Donald Trump's Miracle Coronavirus Cure | Esquire |

FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problem | FDA – Apr. 24, 2020 |

Trump’s chloroquine hype is a misinformation problem bigger than social media | The Verge |

Since late March, President Donald Trump has been promoting the antimalarial drugs chloroquine and hydroxychloroquine as treatments for the novel coronavirus. Among other things, he’s described “strong, powerful signs” that the drugs work and called them potentially “one of the biggest game-changers in the history of medicine.” That will be fantastic if it proves true, but right now, we have no idea. As the hype around the drugs has grown, it’s demonstrated that disinformation isn’t always a social media problem. And it’s forcing platforms and traditional media to grapple with preventing powerful people, not just anonymous trolls, from twisting the truth.

Researchers are still testing hydroxychloroquine, also sold under the name Plaquenil, as a COVID-19 treatment. There’s been a study with tentatively positive results (and some serious limitations), but also a few studies that show little to no therapeutic effect.

Twitter recently removed a video from Brazilian president Jair Bolsonaro, who asserted that the drugs were “working in all cases.” (It also removed Venezuelan president Nicolás Maduro’s claim about a virus-stopping “brew.”) It took down tweets from Trump attorney Rudy Giuliani, who called the treatment “100 percent effective” after touting a New York doctor’s dubious claims about a cure, and Fox News host Laura Ingraham, who misleadingly described a patient’s “Lazarus”-like recovery. Facebook also removed the Bolsonaro video and flagged the “100 percent effective” claim as false.

As the Trump @DC swamp expands: Executive privilege

by Oui on Thu May 21st, 2020 at 08:40:32 AM EST

by Oui on Thu May 21st, 2020 at 09:23:55 AM EST
Another clinical trial across the globe funded by the Gates Foundation ....

COVID-19 Drugs: French Entity Plans To Starts Clinical Trial On Ivermectin To Treat COVID-19 | Thailand Medical News |

Australia's Monash University's Biomedicine Discovery Institute and Peter Doherty Institute of Infection and Immunity at Royal Melbourne Hospital published the results of a study revealing that the drug, an approved anti-parasitic available worldwide, may actually treat against SARS-CoV-2at least when applied to an infected cell culture in a laboratory. The results were very promising as they found after 48 hours the drug was found to have reduced the viral load of the novel coronavirus from 5,000 units to just one unit representing a reduction of 99.98%.

This got the attention of clinical investigators from a French pharmaceutical research venture who decided to further pursue research and clinical trials into Invermectin.

Strategically assessing the current crisis, Professor Jean-Paul Stahl, head of the infectious diseases unit at Grenoble CHU hospital, said, "Ivermectin is an old medicine. Like chloroquine, it is an anti-parasitical drug, but they are not all the same chemical compound.

by Oui on Thu May 21st, 2020 at 10:55:11 AM EST
Didier Raoult looks and sounds like he should have a bone through his nose.
by rifek on Thu May 21st, 2020 at 07:22:16 PM EST
I'm certain you can still sign on for the summer trip ... no coronavirus found by the indigenous people of former Dutch Papua New Guinea ...

A safe journey!

by Oui on Thu May 21st, 2020 at 07:59:48 PM EST
[ Parent ]
I've never acquired a taste for long pig.
by rifek on Fri May 22nd, 2020 at 04:56:49 AM EST
[ Parent ]
by Oui on Fri May 22nd, 2020 at 06:52:38 PM EST
The 4-aminoquinoline antimalarials chloroquine and hydroxychloroquine have been promoted and sometimes used in the treatment of COVID-19, alone or combined with azithromycin, based on their immunomodulatory and antiviral properties, despite an absence of methodologically appropriate proof of their efficacy. The global community awaits the results of ongoing, well powered randomised controlled trials showing the effects of chloroquine and hydroxychloroquine on COVID-19 clinical outcomes. These drugs, however, might be associated with cardiac toxicity.

The findings from Mehra and colleagues' study add to preliminary reports suggesting that regimens of chloroquine or hydroxychloroquine, alone or with azithromycin, are not useful and could be harmful in hospitalised patients with COVID-19.

We declare no competing interests.

by Oui on Fri May 22nd, 2020 at 06:54:25 PM EST
[ Parent ]
Underlying [disease] (based on International Classification of Diseases, tenth revision, clinical modification codes) present in either the inpatient or outpatient electronic health record were collected, which included cardiovascular disease (including coronary artery disease, congestive heart failure, and history of a cardiac arrhythmia), current or previous history of smoking, history of hypertension, diabetes, hyperlipidaemia, or chronic obstructive pulmonary disease (COPD), and presence of an immunosuppressed condition (steroid use, pre-existing immunological condition, or current chemotherapy in individuals with cancer). We collected data on use of medications at baseline, including cardiac medications (angiotensin converting enzyme [ACE] inhibitors, angiotensin receptor blockers, and statins) or use of antiviral therapy other than the drug regimens being evaluated. The initiation of hydroxychloroquine or chloroquine during hospital admission was recorded, including the time of initiation. The use of second-generation macrolides, specifically azithromycin and clarithromycin, was similarly recorded.
For the primary analysis of in-hospital mortality, we controlled for confounding factors, including demographic variables, [cardiovascular diseases?], [comorbid?] disease severity at presentation, and other medication use (cardiac medications and other antiviral therapies).
massaging teh data
To minimise the effect of confounding factors, a propensity score matching analysis was done individually for each of the four treatment groups compared with a control group that received no form of that therapy.

In related US-UK clinical research ...
Exclusive: Russian ventilators reached U.S. states without FDA oversight confounding Ohms Law
Earlier this month, Russia suspended use of some Aventa-M ventilators after six people died in hospital fires that reportedly involved the devices.

U.S. officials have said the ventilators were never supplied to local hospitals, which ultimately did not need as many as feared, and are being returned to FEMA. A New Jersey health official told Reuters the Aventa-M ventilators required an electrical voltage not compatible in the United States.

by Cat on Sat May 23rd, 2020 at 12:29:33 AM EST
[ Parent ]
WHO pauses trial of hydroxychloroquine in COVID-19 patients due to safety concerns
most litigious, known side-effects, "abundance of caution"
archived chloroquine phosphate, chloroquine, and hydroxychloroquine
contra-indicated dosage ("toxicity") and ventricular arrhythmias for each
by Cat on Mon May 25th, 2020 at 06:28:19 PM EST
[ Parent ]
NIH trial: Gilead's drug works best in COVID patients on oxygen
The data detailed in the journal is similar to early results that the NIH released last month from the study, which began in February with 1,063 participants in 10 countries.

Researchers now calculate that after follow up, 7% of patients given remdesivir will have died, compared with 12% in the placebo group, but they said the difference in the death rate was not significant

twitterverse REACTS  < wipes tears >
Remdesivir for the Treatment of Covid-19 -- Preliminary Report, 22 May 2020
"United States (45 sites), Denmark (8), the United Kingdom (5), Greece (4), Germany (3), Korea (2), Mexico (2), Spain (2), Japan (1), and Singapore (1)."
Compassionate Use of Remdesivir for Patients with Severe Covid-19, 10 April 2020
by Cat on Sat May 23rd, 2020 at 01:53:05 AM EST
[ Parent ]
Korea to discuss approving remdesivir for treating COVID-19
With large-scale clinical trials demonstrating the limited effectiveness of remdesivir, an Ebola virus treatment developed by US pharmaceutical company Gilead, in treating COVID-19, South Korean disease control authorities announced on May 25 that they planned to hold discussions with the Ministry of Food and Drug Safety (MFDS) on approval and supplies for its emergency use.
"We are preparing to ask the central clinical committee for its opinion on whether to pursue its emergency use in South Korea, after which we would be making a request with the MFDS," [KCDC Dir Jung Eun-kyeong] explained.
The research team stated in their paper that the study proves that remdesivir has a greater therapeutic effect than a placebo. But they also cautioned that, in light of the high mortality rate, remdesivir should not be administered by itself but should be accompanied by other medications or treatments.
archived $4,000 - $4,500 per patient
by Cat on Wed May 27th, 2020 at 01:27:19 AM EST
[ Parent ]
Someone's in a hurry for ...HERD IMMUNNITY!
by Cat on Thu May 28th, 2020 at 07:04:54 PM EST
[ Parent ]
Plenty to offer ... la Segunda Ola

... or visit Bolsonaro country!

For Brazil one needs to hurry: "Have Coffin, Will Travel!"

'Utter disaster': Manaus fills mass graves as Covid-19 hits the Amazon

by Oui on Thu May 28th, 2020 at 08:27:43 PM EST
[ Parent ]

Due to this amazing retraction of article by The Lancet and the Journal of Medicine!!

Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere


by Oui on Wed Jun 3rd, 2020 at 06:26:18 PM EST
[ Parent ]

.... But Cummings is not a scientist on de SAGE Group like Neil Ferguson. Some pigs are more equal ...

by Oui on Fri May 22nd, 2020 at 09:51:23 PM EST
by Oui on Sat May 23rd, 2020 at 10:25:43 AM EST
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by Oui on Sun May 24th, 2020 at 11:25:05 AM EST
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by Oui on Sun May 24th, 2020 at 11:28:32 AM EST
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by Oui on Sun May 24th, 2020 at 01:02:53 PM EST
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by Oui on Sun May 24th, 2020 at 09:18:57 PM EST
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Tory whips apologise for urging MPs to support Dominic Cummings | The Guardian |

The revelation prompted several senior members of government to tweet their support for Cummings, including the chancellor, Rishi Sunak, the health secretary, Matt Hancock, the foreign secretary, Dominic Raab and Cummings's close ally, Michael Gove.

Inside Downing Street, they believed they could see off damage from the story by focusing on Cummings's wish to protect his son in case both he and his wife were struck down by the disease. A source said: "They were saying, `The kid is the trump card.'"

by Oui on Mon May 25th, 2020 at 06:18:44 AM EST
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by Oui on Mon May 25th, 2020 at 09:03:56 PM EST
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by Oui on Tue May 26th, 2020 at 09:26:55 AM EST
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Dutch PM Mark Rutte did not visit dying mother due to Covid-19 restrictions | The Guardian |

by Oui on Tue May 26th, 2020 at 12:33:51 PM EST
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by Cat on Sat May 23rd, 2020 at 12:17:42 AM EST

The revelation is contained in a report published by the Corporate Observatory Europe (COE), a Brussels-based research centre, examining decisions made by the IMI, which has a budget of €5bn (£4.5bn), made up of EU funding and in-kind contributions from private and other bodies.
The IMI's governing board is made up of commission officials and representatives of the European Federation of Pharmaceutical Industries (EFPIA), whose members include some of the biggest names in the sector, among them GlaxoSmithKline, Novartis, Pfizer, Lilly and Johnson & Johnson.
by Oui on Mon May 25th, 2020 at 04:57:27 AM EST
by Bernard on Tue May 26th, 2020 at 09:32:50 AM EST
[ Parent ]

ONS: Excess UK deaths in Covid-19 outbreak approach 60,000 | The Guardian |

by Oui on Wed May 27th, 2020 at 10:24:43 AM EST
by Oui on Fri Jun 5th, 2020 at 03:07:26 PM EST
by Oui on Fri Jun 5th, 2020 at 03:20:57 PM EST
by Oui on Mon Jun 15th, 2020 at 08:49:26 PM EST
by Oui on Mon Jun 15th, 2020 at 08:52:49 PM EST

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