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Patients Covid-19 Develop Blood Clots

by Oui Fri Mar 12th, 2021 at 09:36:35 AM EST

From the earliest studies, this has been reported. Developing vaccines which induces immunization to the SARS CoV-2 virus may very likely cause such an effect receiving a jab by a minimal number of healthy persons. Having a genetic risk of blood clots in the family, Leyden V blood factor, I'm well aware of the risk and will be critical to the vaccine I will receive. No Russian roulette on not having a choice but just get in line and STFU.

Scott Morrison says AstraZeneca vaccine is safe for Australians after reports of blood clots | The Guardian |


Let Pharma and politicians speak ... it's a lot about business and opening the economy ...

Coronavirus blood-clot mystery intensifies | Nature - May 8, 2020 |

Purple rashes, swollen legs, clogged catheters and sudden death -- blood clots, large and small, are a frequent complication of COVID-19, and researchers are just beginning to untangle why. For weeks, reports have poured in of the disease's effects throughout the body, many of which are caused by clots. "This is like a storm of blood clots," says Behnood Bikdeli, a fourth-year cardiology fellow at Columbia University in New York City. Anyone with a severe illness is at risk of developing clots, but hospitalized patients with COVID-19 seem to be more susceptible.

Studies from the Netherlands and France suggest that clots arise in 20-30% of critically ill COVID-19 patients.

SARS-CoV-2 and coagulation disorders in different organs | Life Sciences |

In this review, we focused on COVID-19 coupled with the coagulopathy contributes to severe outcome inclusive of comorbidities such as venous thromboembolism, stroke, diabetes, lung, heart attack, AKI, and liver injury. Initially, the COVID-19 patient associated coagulation disorders show an elevated level of the D-dimer, fibrinogen, and less lymphocyte count such as lymphopenia. COVID-19 associated with the Kawasaki disease has acute vasculitis in childhood which further affects the vessels found all over the body.

COVID-19 linked with the thrombotic microangiopathy triggers the multiple vasculitis along with the arterioles thrombosis, medium, large venous and arterial vessels mediates the disseminated intravascular coagulation (DIC). SARS-Co-V-2 patients have reduced primary platelet production, increased destruction of the platelet, decreased circulating platelet leads to the condition of increased thrombocytopenia which contributes to the coagulation disorder.

Massive inflammatory response, the cytokine storm | John Hopkins |

COVID-19 and Blood Clots | Harvard - Nov. 9, 2020 |

Patients hospitalized with severe COVID-19 infections who have high levels of the blood clotting protein Factor V are at elevated risk for serious injury from blood clots such as deep vein thrombosis or pulmonary embolism, according to a new study by Harvard Medical School investigators at Massachusetts General Hospital.

On the other hand, critically ill patients with COVID-19 and low levels of factor V appear to be at increased risk for death from a form of coagulopathy that resembles disseminated intravascular coagulation (DIC)--a devastating, often fatal abnormality in which blood clots form in small vessels throughout the body, leading to exhaustion of clotting factors and proteins that control coagulation.

Their findings, based on studies of patients with COVID-19 in Mass General intensive care units, point to disturbances in factor V activity as both a potential cause of blood clotting disorders with COVID-19 and potential methods for identifying at-risk patients with the goal of selecting the proper anticoagulation therapy.

Can Autoimmune Antibodies Explain Blood Clots in COVID-19?

Our blood vessels normally strike a balance between producing clotting and anti-clotting factors. This balance keeps us ready to seal up vessels after injury, but otherwise to keep our blood flowing at just the right consistency so that neutrophils and platelets don’t stick and form clots at the wrong time. But previous studies have suggested that SARS-CoV-2 can tip the balance toward promoting clot formation, raising questions about which factors also get activated to further drive this dangerous imbalance.

To learn more, a team of physician-scientists, led by Yogendra Kanthi, a newly recruited Lasker Scholar at NIH’s National Heart, Lung, and Blood Institute and his University of Michigan colleague Jason S. Knight, looked to various types of aPL autoantibodies. These autoantibodies are a major focus in the Knight Lab’s studies of an acquired autoimmune clotting condition called antiphospholipid syndrome. In people with this syndrome, aPL autoantibodies attack phospholipids on the surface of cells including those that line blood vessels, leading to increased clotting. This syndrome is more common in people with other autoimmune or rheumatic conditions, such as lupus.

It’s also known that viral infections, including COVID-19, produce a transient increase in aPL antibodies. The researchers wondered whether those usually short-lived aPL antibodies in COVID-19 could trigger a condition similar to antiphospholipid syndrome.

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by Oui on Fri Mar 12th, 2021 at 05:07:46 PM EST

Covid-19: Several European countries suspend AstraZeneca vaccinations over blood clot fears | France24 |

by Oui on Fri Mar 12th, 2021 at 05:35:53 PM EST
by Oui on Fri Mar 12th, 2021 at 05:37:31 PM EST
Rockville man says rare blood disorder flared after COVID-19 vaccination | WUSA9 - March 9, 2021 |

A Rockville man said he nearly died after getting the Pfizer vaccine.

...
"FDA is aware of reports of a serious condition called thrombocytopenia, or low levels of platelets in the blood, occurring in a few individuals following receipt of the authorized COVID-19 vaccines," said Food and Drug Administration spokeswoman Abby Capobianco. "Thrombocytopenia can have many different causes. At this time, we are continuing our investigation and assessment of these cases."

"You can argue it's a coincidence. You can argue it's a fluke. But when it's your life, it's very real," Dhami said. The cybersecurity analyst was diagnosed with thrombocytopenia when he was in his 20s, but it was under control until he was vaccinated for COVID-19.

"We take reports of adverse events very seriously. We are aware of cases of thrombocytopenia in recipients of our COVID-19 vaccine as reported to the (Vaccine Adverse Event Reporting System) and/or reported to Pfizer. We are collecting relevant information to share with the FDA. However, at this time, we have not been able to establish a causal association with our vaccine," Pfizer spokesman Steven Danehy said.

Doctors search for missing link between COVID-19 and ITP | MDedge Hematology - Jan. 28, 2021 |

by Oui on Fri Mar 12th, 2021 at 06:46:14 PM EST
EU regulator investigates COVID vaccines for link to bleeding disorder | Reuters |

The agency said it would assess reports of the condition in people who had received the Pfizer/BioNTech, AstraZeneca or Moderna vaccines.

European vaccination programmes have been upset in the last two weeks by reports that recipients of the AstraZeneca inoculation have suffered blood clots.

by Oui on Fri Mar 12th, 2021 at 09:26:16 PM EST
by Oui on Fri Mar 12th, 2021 at 09:26:46 PM EST
U.S. not planning to share AstraZeneca vaccine stockpile with other countries | NBC News |

U.S. secures 300 million doses of potential AstraZeneca COVID-19 vaccine | Reuters - May 21, 2020 |

US is sitting on tens of millions of coronavirus vaccine doses that the world needs | Economic Times |

About 30 million doses are currently bottled at AstraZeneca's facility in West Chester, Ohio. Emergent BioSolutions, a company in Maryland that AstraZeneca has contracted to manufacture its vaccine in the United States, has also produced enough vaccine in Baltimore for tens of millions more doses once it is filled into vials and packaged, the official said.

The fate of those doses of AstraZeneca's vaccine is the subject of an intense debate among White House and federal health officials, with some arguing the administration should let them go abroad where they are desperately needed, while others are not ready to relinquish them, according to senior administration officials.

AstraZeneca is involved in those conversations.

"We understand other governments may have reached out to the U.S. government about donation of AstraZeneca doses, and we've asked the U.S. government to give thoughtful consideration to these requests," said Gonzalo Viña, a spokesperson for AstraZeneca.

by Oui on Fri Mar 12th, 2021 at 09:43:14 PM EST
by Oui on Mon Mar 15th, 2021 at 03:37:17 PM EST
by Oui on Mon Mar 15th, 2021 at 04:17:17 PM EST
[ Parent ]
Appears to be a rare blood disorder, a complication not often seen that drew attention, not simply "blood clots."

Germany, France and Italy suspend Oxford Covid vaccine

The agency said in a statement that the woman had "a low number of blood platelets and clots in small and large vessels, as well as bleeding". Norway also spoke of "unusual symptoms" in three people under 50 being treated in hospital. Two health workers in Norway have since died of brain haemorrhages, the national medicines agency said, adding that it could "neither confirm nor exclude that it has something to do with the vaccine".
Austria stopped using one batch of the AstraZeneca vaccine on 8 March after a 49-year-old nurse died from "severe bleeding disorders", and prosecutors in the northern Italian region of Piedmont on Monday seized a batch of 393,600 doses after a 57-year-old music teacher fell ill and died.

by Oui on Mon Mar 15th, 2021 at 05:05:56 PM EST
[ Parent ]
by Oui on Mon Mar 15th, 2021 at 06:28:45 PM EST
[ Parent ]
Prof Jon Gibbins, Director of the Institute for Cardiovascular and Metabolic Research at the University of Reading

"Blood clotting, or thrombosis, occurs for a variety of reasons, the lead up to an even can often be undetected in the general population, and venous thrombosis is relatively common affecting 1 to 2 in 1000.  Risk of thrombosis increases with age, although it can occur at any age, and there are additional risks for some underlying health conditions.

"The Paul Erlich Institute in Germany have announced that they are investigating events of Sinus Vein Thrombosis as a possible adverse reaction to the AstraZeneca vaccine, which is notable. Cranial Sinus Vein Thrombosis (CVST) is a rare type of thrombosis affecting 5 in one million patients and causes a stroke, and generally takes place in patients with abnormal platelets which may become hyper-activated in certain circumstances.

The specific circumstances in Germany are still not clear here and they have provided cautionary advice that anyone with severe and persistent headaches or pin-prick skin bleeding seek medical attention as a matter of priority."

NIH 'Very Concerned' About Serious Side Effect in Coronavirus Vaccine Trial | Sept. 14, 2020 |

Q&A: How serious are the AstraZeneca vaccine safety concerns? | Irish Times |

by Oui on Mon Mar 15th, 2021 at 09:11:03 PM EST
[ Parent ]
There are a number of observations which point to link of jab with Oxford vaccine. The symptoms in these cases start seven days after jab. Adequate treatment is possible, but there should be no delay for intervention.

Dane who died from blood clot after AstraZeneca shot had 'unusual symptoms', agency says | Reuters |

COPENHAGEN - A 60-year old Danish woman who died of a blood clot after receiving AstraZeneca's COVID-19 vaccine had "highly unusual" symptoms, according to the Danish Medicines Agency.

The woman had a low number of blood platelets and clots in small and large vessels, as well as bleeding, it said.

...
"It was an unusual course of illness around the death that made the Danish Medicines Agency react," it said in a statement late on Sunday.

Norway said on Saturday that three people, all under the age of 50, who had received the AstraZeneca vaccine were being treated in hospital for bleeding, blood clots and a low count of blood platelets, which were labeled "unusual symptoms" by health authorities.

Denmark, Norway and Iceland said last week they would halt the introduction of the AstraZeneca vaccine.

by Oui on Tue Mar 16th, 2021 at 09:17:33 AM EST
[ Parent ]
by Oui on Tue Mar 16th, 2021 at 08:49:40 AM EST
Medical specialist at Leiden University Medical Center has not once come across this complication by a patient. Prof. Menno  Huisman gave scientific explanation of the reasoning for national entities to suspend vaccination and await meeting EMA for a review. Oxford/AstraZeneca yet to be approved by FDA for emergency use 😌.

by Oui on Tue Mar 16th, 2021 at 08:50:45 AM EST
by Oui on Tue Mar 16th, 2021 at 05:18:31 PM EST
by Oui on Thu Mar 18th, 2021 at 04:49:04 PM EST
[ Parent ]

COVID: BioNTech-Pfizer speeds up vaccine delivery to EU | DW |
by Oui on Tue Mar 16th, 2021 at 08:42:29 PM EST
Boris Johnson pilfering Covax sourced supply of AZ vaccines from it's Commonwealth nation India ... common wealth... What's In A Name?

It was in that optimistic context that the UK announced it was acquiring 10m doses from the Serum Institute of India, the world's largest vaccine manufacturer and the key source of doses for Covax, a vaccine-sharing agreement on which poor and middle-income countries are relying.

UK Covid vaccine supply hit amid rise in cases in India

by Oui on Thu Mar 18th, 2021 at 05:33:09 PM EST

India Shipment of Astra Vaccine Said to Be Behind U.K. Delay | Bloomberg |

A delayed shipment of AstraZeneca Plc's Covid-19 vaccine from India and a batch requiring re-testing are behind a cut in the U.K.'s supply starting this month, the first major interruption in Britain's vaccine rollout.

Vaccine doses made by one of Astra's manufacturing partners, the Serum Institute of India Ltd., have been stalled, and another 1.7 million shots have been kept back in the last week for further checks on their stability, U.K. Health Secretary Matt Hancock told Parliament in a statement Thursday. The Serum delays account for four million doses, according to the U.K. Department of Health and Social Care.

by Oui on Thu Mar 18th, 2021 at 06:20:51 PM EST
[ Parent ]

Britain's Medicines and Healthcare products Regulatory Agency (MHRA) said that use of the vaccine should continue while five reports were investigated, and one official said that the rollout would likely continue even if a link was proved.

"There is no evidence that blood clots in veins is occurring more than would be expected in the absence of vaccination, for either vaccine," said June Raine, MHRA Chief Executive, referring to AstraZeneca and Pfizer shots.

...
One of the reported cases was fatal, MHRA Vaccine Safety Lead Philip Bryan said, adding that the cases were all among men aged between 19 and 59.

NO PAUSE NECESSARY

The MHRA said anyone with a headache that lasts for more than four days after vaccination, or bruising beyond the site of vaccination after a few days, should seek medical attention.

Coronavirus Vaccine -summary of Yellow Card reporting | MHRA |

by Oui on Thu Mar 18th, 2021 at 07:07:20 PM EST
Beside the usual problems with mass vaccinations:

Get Ready for False Side Effects

We're talking about treating very, very large populations, which means that you're going to see the usual run of mortality and morbidity that you see across large samples. Specifically, if you take 10 million people and just wave your hand back and forth over their upper arms, in the next two months you would expect to see about 4,000 heart attacks. About 4,000 strokes. Over 9,000 new diagnoses of cancer. And about 14,000 of that ten million will die, out of usual all-causes mortality. No one would notice. That's how many people die and get sick anyway.

The greater the number of people vaccinated the greater the number falling in the uttermost left or right areas under the curve.  Meaning there is statistical certainty there will be adverse affects attributable to the vaccine.  

It's a question of: how many tens of thousands are you willing to let die from Covid-19 to protect the tens dying from the vaccine?


She believed in nothing; only her skepticism kept her from being an atheist. -- Jean-Paul Sartre

by ATinNM on Fri Mar 19th, 2021 at 03:06:19 PM EST
Very true ... it's more of a scientific question to understand the effects of the Covid-19 vaccines.

The caution should for longterm effects, but there also the inoculation likely dwarfs the hardship of Covid-19 patients, the "long haulers."

In Europe, countries are going into lockdown due to the third wave ... the global battle is to get the vaccines in quantities as early as possible.

Call a physician when a headache endures longer than 3 days after a jab 😟

by Oui on Fri Mar 19th, 2021 at 04:32:59 PM EST
[ Parent ]
Finland suspends AstraZeneca vaccine despite European regulator saying it is safe and effective | EuroNews |

The country's public health authority said two people developed blood clots after being vaccinated. As a result, jabs will be suspended "until there is more information and a possible causality can be assessed".

Norway, Sweden and Denmark continue pause on vaccination

Geir Bukholm, the director of the Division of Infection Control at the Norwegian Institute for Public Health, said the vaccination pause would continue in Norway.

    Vaccinations with AstraZeneca will be resumed no earlier than Monday, March 29.

    According to the Pharmaceutical Safety and Development Center Fimea, two cerebral venous thrombosis have been reported in Finland 4-10 days after receiving the Astra Zeneca coronary vaccine. However, the observed exceptional symptoms are very rare according to THL. So far, there is no certainty as to whether the observed coagulation disorders are related to vaccination.

    Liisa Näveri, Head of Fimea's Pharmacovigilance Unit, stated at the press conference that the notifications have come in the next few days, and until recent days, no cases of vascular infections had been detected in Finland.

by Oui on Fri Mar 19th, 2021 at 10:29:26 PM EST
[ Parent ]
Coronavirus digest: Denmark reports two blood-clot cases after AstraZeneca jab | DW News |

Denmark says two people have developed blood clots and cerebral hemorrhage after receiving the AstraZeneca vaccine.

The Capital Region of Denmark, the authority that runs public hospitals in Copenhagen, said that one of the people had died. Both were hospital staff and had received the AstraZeneca vaccine less than two weeks before becoming ill, it said. It was not reported when the people had developed the symptoms.

by Oui on Sat Mar 20th, 2021 at 06:23:09 PM EST
[ Parent ]
Due to side effects with mortality risk, one has the best benefits ratings where risk of dying from Corona is the highest. No?

A rare clotting disorder may cloud the world's hopes for AstraZeneca's COVID-19 vaccine | ScienceMag - March 27, 2021 |

Many countries are, for now, accept the risk that the AstraZeneca may carry, but several have restricted its use to people who are at the highest risk of dying from COVID-19: those aged 55 or older in France, 65 or older in Sweden and Finland, and 70 or older in Iceland. That approach makes sense, says Sandra Ciesek, a virologist at Goethe University Frankfurt. "The argument I keep hearing is that the risk-benefit ratio is still positive. But we do not have just one vaccine, we have several. So restricting the AstraZeneca vaccine to older people makes sense to me, and it does not waste any doses."

Denmark and Norway are waiting for more data. Norway, which has administered the AstraZeneca vaccine to 130,000 people under 65, has reported five patients who had low platelets, hemorrhage, and widespread thromboses, three of whom died. That's about one case in 25,000 vaccinees, "a high number with a very critical outcome in previously healthy, young individuals," says Watle.

Vaccinations in most EU countries resumed after a few days ...

European Medicines Agency (EMA) recommended doing so on 18 March, saying the benefits of the vaccine outweigh any risks. EMA is continuing to investigate the matter and will convene a wideranging committee of experts on 29 March.

by Oui on Sun Mar 28th, 2021 at 06:57:38 AM EST

Coronavirus: L'Agence du medicament confirme un risqué de thrombose "rare" associée au vaccin AstraZeneca [link]

by Oui on Sun Mar 28th, 2021 at 07:47:37 PM EST
Cinzia Pennino è morta a causa di una trombosi dopo che le era stato somministrato il vaccino Astrazeneca

Uniklinik in Rostock setzt Impfungen für Risikogruppen aus

Nach ihrer Astrazeneca-Impfung ist in Rostock eine 49-Jährige Mitarbeiterin der Uni-Klinik gestorben. Nun zieht die Klinik Konsequenzen.

In Rostock ist eine 49-jährige Frau zwölf Tage nach einer Corona-Impfung mit dem Wirkstoff Astrazeneca gestorben. Weil ein Zusammenhang mit der Impfung bislang nicht ausgeschlossen werden kann, will die Unimedizin Rostock bestimmte Personengruppen nun vorerst nicht mehr mit Astrazeneca impfen.

Wie der NDR berichtet, sollen Mensen mit Bluthochdruck oder Übergewicht vorerst keine Impfungen mehr mit Astrazeneca bekommen- von der Aussetzung betroffen sind auch Frauen, die die Pille nehmen. 1.000 Mitarbeiterinnen und Patienten der Unimedizin seien bereits mit dem Impfstoff geimpft worden, Astrazeneca sei ein gut wirkender Impfstoff, so der Sprecher.

by Oui on Sun Mar 28th, 2021 at 07:51:04 PM EST

Canada suspends use of AstraZeneca Covid vaccine for those under 55 | The Guardian |

Canada on Monday suspended the use of the Oxford/AstraZeneca coronavirus vaccine for people under 55 following concerns it might be linked to rare blood clots.

The pause was recommended by the National Advisory Committee on Immunization for safety reasons. The Canadian provinces, which administer health in the country, announced the suspension on Monday.

"There is substantial uncertainty about the benefit of providing AstraZeneca Covid-19 vaccines to adults under 55 given the potential risks," said Dr Shelley Deeks, vice-chair of the National Advisory Committee on Immunization.

Deeks said the updated recommendations came amid new data from Europe that suggests the risk of blood clots is now potentially as high as one in 100,000, much higher than the one in one million risk believed before.

by Oui on Tue Mar 30th, 2021 at 05:49:23 AM EST
by Oui on Tue Mar 30th, 2021 at 05:58:01 AM EST
[ Parent ]

The Netherlands follows Canada, Germany and others to suspend Oxford AstraZeneca for the second time due to rare blood clots seen in patients.

by Oui on Fri Apr 2nd, 2021 at 07:17:29 PM EST
[ Parent ]

Berlin state hospitals pause AstraZeneca shots for women staff under 55 | Reuters |

by Oui on Tue Mar 30th, 2021 at 12:23:54 PM EST
[ Parent ]

Germany's chancellor Angela Merkel and the health minister Jens Spahn are due to hold a video conference on Tuesday evening with the governors of Germany's 16 regions to discuss the next steps regarding the AstraZeneca shot. The hastily convened meeting will be followed by a press conference.

Germany was one of a number of countries in Europe that suspended use of the AstraZeneca jab earlier this month over concerns it may cause blood clots. But many of them reinstated the vaccine after the European Medicines Agency insisted it was safe to use.

Germany's potential volte-face is a fresh blow to Europe's mass inoculation campaign, just as it was beginning to pick up speed after a sluggish start over the winter, and it could hurt the international reputation of the AstraZeneca shot.

France has limited use of the AstraZeneca vaccine to the over 55s and Sweden has limited it to the over 65s. Norway and Denmark extended their complete suspension of the vaccine for another three weeks on 26 March.

by Oui on Tue Mar 30th, 2021 at 07:16:18 PM EST
[ Parent ]
by Oui on Tue Mar 30th, 2021 at 07:17:14 PM EST
[ Parent ]
UK medicines watchdog finds 30 blood clot cases after AstraZeneca vaccinations

The UK's medicines watchdog has identified 30 cases of rare blood clots in people who have received the AstraZeneca Covid-19 vaccine -- 25 more than previously reported.

It added that the cases were still very rare and advises the vaccine continue to be used, as the benefits outweigh the risk.

    The Medicines and Healthcare products Regulatory Agency (MHRA) said it received 22 reports of cerebral venous sinus thrombosis -- a blood clot in the sinuses that drains blood from the brain -- and eight reports of other thrombosis events where the person's blood platelet counts were low.

    These were out of a total of 18.1 million doses of the vaccine given in the UK by March 24.

    The MHRA said that as of March 21, there were no reports of blood clots for the Pfizer/BioNTech vaccine, though the UK has purchased significantly fewer doses of that shot.

The European Medicines Agency and the World Health Organization also said the vaccination should continue, though several other countries have either paused or limited its use, pending investigation.

EMA: AstraZeneca COVID-19 vaccine: review of very rare cases of unusual blood clots continues | March 31, 2021 |

by Oui on Fri Apr 2nd, 2021 at 01:36:01 PM EST

This message you won't find on the MHRA Twitter account ...

UK regulator found total of 30 cases of blood clot events after AstraZeneca vaccine use | Reuters |

by Oui on Fri Apr 2nd, 2021 at 01:37:04 PM EST
[ Parent ]
Study link ...

Messenger RNA (mRNA) COVID-19 vaccines have been shown to be effective in preventing symptomatic SARS-CoV-2 infection in randomized placebo-controlled Phase III trials

The findings complement and expand upon these preceding reports by demonstrating that the vaccines can also reduce the risk for infection regardless of COVID-19-associated illness symptom status (4,5). Reducing the risk for transmissible infection, which can occur among persons with asymptomatic infection or among persons several days before symptoms onset (6), is especially important among health care personnel, first responders, and other essential and frontline workers given their potential to transmit the virus through frequent close contact with patients and the public.

Conclusion: vaccination does limit virus shredding by a-symptomatic persons and prevent high level of infection.

by Oui on Sat Apr 3rd, 2021 at 04:34:18 PM EST
COVID-19 wards shutting down across Israel due to rapid vaccinations | JPost |

by Oui on Sat Apr 3rd, 2021 at 04:35:56 PM EST
[ Parent ]
by Oui on Tue Apr 6th, 2021 at 05:53:14 PM EST
by Oui on Tue Apr 6th, 2021 at 05:53:42 PM EST
[ Parent ]
by Oui on Tue Apr 6th, 2021 at 05:54:56 PM EST
The BBC headline says "paused" ... don't use children as guinea pigs for BIG Pharma and profits!

    Oxford and Eton Want to Prove A Point??
by Oui on Tue Apr 6th, 2021 at 06:00:02 PM EST
by Oui on Wed Apr 7th, 2021 at 02:23:02 PM EST
[ Parent ]

Does anyone know the predictability of variants, consequences of SARS-CoV-2 virus or the modern vaccines in patients: the long haul or ill side-effects.

by Oui on Tue Apr 6th, 2021 at 06:01:08 PM EST
Does anyone know the predictability of variants

We can predict SARS-CoV-2 will continue to mutate.  Single Strand RNA viruses are highly prone to mutation due to their lack of molecular error detection and correction mechanisms.  

consequences of SARS-CoV-2 virus

Until we have completed global vaccination we can predict lots more dead people, some number of people having functional to dysfunctional brain damage, and some number of people having functional to dysfunctional heart damage.  We're only at the end of the beginning of this pandemic.  We can get a glimpse from looking at countries that adequately and correctly   responded: China, Viet Nam, New Zealand; they seem to be mostly back to normal.

[consequences of] the modern vaccines in patients: the long haul or ill side-effects.

We know people who get the vaccine are HIGHLY less likely to contract the disease so Not Dying is one consequence.  You already know about AZ and blood clots.  The long haul side-effects are a Known Unknown.  

She believed in nothing; only her skepticism kept her from being an atheist. -- Jean-Paul Sartre

by ATinNM on Wed Apr 7th, 2021 at 04:04:56 PM EST
[ Parent ]
Mysterious Ailment, Mysterious Relief: Vaccines Help Some COVID Long-Haulers

The notion that a vaccine aimed at preventing the disease may also be a treatment has sparked optimism among patients, and scientists who study the post-illness syndrome are taking a close look at these stories.

"I didn't expect the vaccine to make people feel better," says Akiko Iwasaki, an immunologist at the Yale School of Medicine who's researching long COVID.

...
There are several leading theories for why vaccines could alleviate the symptoms of long COVID: It's possible the vaccine clears up leftover virus or fragments, interrupts a damaging autoimmune response, or in some other way "resets" the immune system.

"It's all biologically plausible and importantly should be easy to test," says Dr. Steven Deeks of the University of California, San Francisco, who is also studying the long-term impacts of the coronavirus on some patients.

The vaccines causes autoimmune response that may overreact and induce the exceptional blood clots and low platelet count.

EU drug watchdog reviewing possible blood clot links with Johnson & Johnson Covid vaccine

by Oui on Fri Apr 9th, 2021 at 04:49:45 PM EST
[ Parent ]
We're at the point in the US where we can start ball-parking numbers.

6.8 million doses of the J&J vaccine have been given.  To date there has been one death and one person in critical care.  

Roughly 10% of the US population has contracted Covid-19 or 32,000,000 (and a bit) or ~10% of the US population.  Of that 578,098 have died giving a 2% death rate.

So.

Without the vaccine we can estimate out of the 6,800,000 we can estimate 680,000 cases with the 2% death rate of 13,600 deaths.  With the vaccine, and using a low 64% efficiency rate we get 15 cases per 100,000 or 1,020 cases and 21 deaths.  

And there you have it.  Need to balance:

No vaccine: 13,600 deaths

versus

J&J vaccine:  21 + 1 = 22 deaths

Plus - CDC numbers - tell use

The precise number of people affected by [of venous thromboembolism] is unknown, although as many as 900,000 people could be affected (1 to 2 per 1,000) each year in the United States. Estimates suggest that 60,000-100,000 Americans die

Indicating we may*, or may not, be looking at a Post Hoc Ergo Proptor Hoc Fallacy aka False Side Effect.  

We should have more & better data in a couple of weeks.  Until then halting the J&J vaccination program is, IMO, unjustified given the balance of deaths, above.

* Note emphasis


She believed in nothing; only her skepticism kept her from being an atheist. -- Jean-Paul Sartre

by ATinNM on Thu Apr 15th, 2021 at 06:44:01 PM EST
[ Parent ]
by Oui on Wed Apr 7th, 2021 at 12:35:46 PM EST
by Oui on Wed Apr 7th, 2021 at 02:16:46 PM EST
[ Parent ]


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